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Int J Biol Sci 2024; 20(7):2491-2506. doi:10.7150/ijbs.95316 This issue Cite

Research Paper

The Effect Mechanism of N6-adenosine Methylation (m6A) in Melatonin Regulated LPS-induced Colon Inflammation

Yuanyuan Li1, Baochen Ma2, Zixu Wang1, Yaoxing Chen1, Yulan Dong1✉

1. Laboratory of Neurobiology, College of Veterinary Medicine, China Agricultural University, Beijing, People's Republic of China.
2. Key Laboratory of Precision Nutrition and Food Quality, Ministry of Education, Department of Nutrition and Health, China Agricultural University, Beijing, People's Republic of China.

✉ Corresponding author: No. 2, Yuanmingyuan West Road, Haidian District, Beijing, 100193, People's Republic of China. Yulan Dong, E-mail: ylbcdongedu.cn.

Citation:
Li Y, Ma B, Wang Z, Chen Y, Dong Y. The Effect Mechanism of N6-adenosine Methylation (m6A) in Melatonin Regulated LPS-induced Colon Inflammation. Int J Biol Sci 2024; 20(7):2491-2506. doi:10.7150/ijbs.95316. https://www.ijbs.com/v20p2491.htm
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Abstract

Graphic abstract

Colon inflammation is characterized by disturbances in the intestinal microbiota and inflammation. Melatonin (Mel) can improve colon inflammation. However, the underlying mechanism remains unclear. Recent studies suggest that m6A methylation modification may play an important role in inflammatory responses. This study aimed to explore the effects of melatonin and LPS-mediated m6A methylation on colon inflammation. Our study found that melatonin inhibits M1 macrophages, activates M2 macrophages, inhibit the secretion of pro-inflammatory factors, maintain colon homeostasis and improves colon inflammation through MTNR1B. In addition, the increased methylation level of m6A is associated with the occurrence of colon inflammation, and melatonin can also reduce the level of colon methylation to improve colon inflammation. Among them, the main methylated protein METTL3 can be inhibited by melatonin through MTNR1B. In a word, melatonin regulates m6A methylation by improving abnormal METTL3 protein level to reshape the microflora and activate macrophages to improve colon inflammation, mainly through MTNR1B.

Keywords: Melatonin, Inflammation, Mettl3, Gut Microbiota, Macrophage

Citation styles

APA
Li, Y., Ma, B., Wang, Z., Chen, Y., Dong, Y. (2024). The Effect Mechanism of N6-adenosine Methylation (m6A) in Melatonin Regulated LPS-induced Colon Inflammation. International Journal of Biological Sciences, 20(7), 2491-2506. https://doi.org/10.7150/ijbs.95316.

ACS
Li, Y.; Ma, B.; Wang, Z.; Chen, Y.; Dong, Y. The Effect Mechanism of N6-adenosine Methylation (m6A) in Melatonin Regulated LPS-induced Colon Inflammation. Int. J. Biol. Sci. 2024, 20 (7), 2491-2506. DOI: 10.7150/ijbs.95316.

NLM
Li Y, Ma B, Wang Z, Chen Y, Dong Y. The Effect Mechanism of N6-adenosine Methylation (m6A) in Melatonin Regulated LPS-induced Colon Inflammation. Int J Biol Sci 2024; 20(7):2491-2506. doi:10.7150/ijbs.95316. https://www.ijbs.com/v20p2491.htm

CSE
Li Y, Ma B, Wang Z, Chen Y, Dong Y. 2024. The Effect Mechanism of N6-adenosine Methylation (m6A) in Melatonin Regulated LPS-induced Colon Inflammation. Int J Biol Sci. 20(7):2491-2506.

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