International Journal of Biological Sciences

ISSN 1449-2288

International Journal of Medical Sciences

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Int J Biol Sci 2008; 4:245-245 ©Ivyspring International Publisher

Letter To The Editor

In reply to Zou et al. “New amyloid plaques or a game of hide-and-seek?”

Bradley Hyman

Massachusetts General Hospital, MassGeneral Institute for Neurodegeneration, Charlestown MA 02129, USA

How to cite this article:
Hyman B. In reply to Zou et al. “New amyloid plaques or a game of hide-and-seek?”. Int J Biol Sci 2008; 4:245-245. Available from http://www.biolsci.org/v04p0245.htm

Reply to the article: Zou K, Maeda T, Michikawa M, Komano H. New amyloid plaques or a game of hide-and-seek? Int J Biol Sci 2008; 4:200-201.

We appreciate, but disagree with, Zou et al's comments regarding potential technical issues in the in vivo imaging. Our control experiments, including explicit criteria for inclusion and exclusion of new plaques, the presence of other plaques in the field that are observed by the dyes, the use of different freely diffusible well characterized dyes (both topical application and intraperitoneal application for a dye that that we have previously formally demonstrated to readily cross the blood brain barrier) and concurrent imaging of neurites and blood vessels to ensure quality of imaging per se all, in our opinion, argue against their concerns.

Author contact

Corresponding address Correspondence to: Bradley Hyman MD PhD, John B Penney Jr Professor of Neurology Harvard Medical School, Massachusetts General Hospital, MassGeneral Institute for Neurodegeneration Rm 2009, 114 16th Street, Charlestown MA 02129.

Published 2008-8-8