International Journal of Biological Sciences

International Journal of Medical Sciences

Editor-in-Chief: Chuxia Deng, PhD, National Institutes of Health*, Bethesda, MD
* Dr. Deng is serving in his personal capacity.
Editor-in-Chief's Profile

The latest impact factor of IJBS is 3.215, up from previous 2.865. This puts the journal in the top 15.4% of all SCI journals, up from previous 18.4%. Congratulation!
Indexed/covered by MEDLINE, PubMed, Science Citation Index (SCI) Expanded, Current Contents®/Life Sciences, EMBASE, CAS, CABI, Scopus (full index information)
Full texts of articles in PubMed Central, UK PMC, and PMC Canada.
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This Journal is ranked among the top 2.1% of journals (29/1380) according to SCImago in the area of Agricultural and Biological Sciences ...details

Top cited papers:

TM Thornton & M Rincon. Non-Classical P38 Map Kinase Functions: Cell Cycle Checkpoints and Survival. Cited by 80
HB Shao et al. Primary antioxidant free radical scavenging and redox signaling pathways in higher plant cells. Cited by 112
JK Lunney. Advances in Swine Biomedical Model Genomics. Cited by 122
DP Siderovski & FS Willard. The GAPs, GEFs, and GDIs of heterotrimeric G-protein alpha subunits. Cited by 138

Most Cited Paper Award: Winners of this year are Tina M. Thornton and Mercedes Rincon from University of Vermont, "Non-Classical P38 Map Kinase Functions: Cell Cycle Checkpoints and Survival ". Cited by 80. Winners of previous years were Hong-Bo Shao et al. "Primary antioxidant free radical scavenging and redox signaling pathways in higher plant cells", and Joan K. Lunney "Advances in Swine Biomedical Model Genomics". ...details

Special issue on the current knowledge of IL-6. Guest editor: Mercedes Rincon, University of Vermont.

Pancreatitis occurs when digestive enzymes are activated in the pancreas. Severe pancreatitis has a 10-30% mortality rate. No specific treatments for pancreatitis exist now. Here, Feng et al. discovered that interleukin-22 (IL-22) may have therapeutic potential in treating acute and chronic pancreatitis. Wild-type and IL-22 knockout mice were equally susceptible to ceru-lein-induced acute and chronic pancreatitis, whereas liver-specific IL-22 transgenic mice were completely resistant to cerulein-induced elevation of serum digestive enzymes, pancreatic necrosis and apoptosis, and inflammatory cell infiltration. Treatment of wild-type mice with recombinant IL-22 or adenovirus IL-22 markedly attenuated the severity of cerulein-induced acute and chronic pancreatitis. ...details

Kaposi sarcoma-associated herpesvirus (KSHV) is a causative agent for Kaposi sarcoma and primary effusion lymphoma. KSHV encodes a viral ORF57 (also named Mta) to regulate viral gene expression by enhancing viral RNA splicing and stability. In this study, we identified viral PAN RNA, a long non-coding polyadenylated nuclear RNA, as a main target of ORF57 by a genome-wide CLIP (cross-linking and immunoprecipitation) approach. KSHV genome lacking ORF57 expresses only a minimal amount of PAN. In cell cotransfection, ORF57 increased PAN expression by 20-30-fold. ...details

Mouse protein tyrosine phosphatase PTPBR7 is a receptor-like, transmembrane protein that is localized on the surface of neuronal cells. Its protein phosphatase activity is reduced upon multimerization, and PTPBR7-deficient mice display motor coordination defects. Extracellular molecules that may influence PTPBR7 activity, however, remain to be determined. We here show that the PTPBR7 extracellular domain binds to highly myelinated regions in mouse brain, in particular the white matter tracks in cerebellum. PTPBR7 deficiency does not alter this binding pattern, as witnessed by RAP in situ staining of Ptprr^-/- mouse brain sections. ...details

Traditional wisdom holds that intact immune responses, such as immune surveillance or immunoediting, are required for preventing and inhibiting tumor development; but recent evidence has also indicated that unresolved immune responses, such as chronic inflammation, can promote the growth and progression of cancer. Within the immune system, cytotoxic CD8⁺ and CD4⁺ Th1 T cells, along with their characteristically produced cytokine IFN-γ, function as the major anti-tumor immune effector cells, whereas tumor associated macrophages (TAM) or myeloid-derived suppressive cells (MDSC) and their derived cytokines IL-6, TNF, IL-1β and IL-23 are generally recognized as dominant tumor-promoting forces. ...details

Signal transducer and activator of transcription 3 (STAT3) is a transcription factor that is activated by many cytokines and growth factors and plays a key role in cell survival, proliferation, and differentiation. STAT3 activation is detected virtually in all rodent models of liver injury and in human liver diseases. In this review, we highlight recent advances of STAT3 signaling in liver injury, steatosis, inflammation, regeneration, fibrosis, and hepatocarcinogenesis. The cytokines and small molecules that activate STAT3 in hepatocytes may have therapeutic benefits to treat acute liver injury, fatty liver disease, and alcoholic hepatitis, while blockage of STAT3 may have a therapeutic potential to prevent and treat liver cancer. ...details

IJBS issue cover

Research Paper
Selective Accumulation of Th2-skewing Immature Erythroid Cells in Developing Neonatal Mouse Spleen
Mercedes R. Rincon, Karen Oppenheimer, Elizabeth A. Bonney
Int. J. Biol. Sci. 2012; 8(5): 719-730. doi:10.7150/ijbs.3764
[Abstract] [Full text] [PDF]

Research Paper
Combined Preconditioning and Postconditioning Provides Synergistic Protection against Liver Ischemic Reperfusion Injury
Xiaoyu Song, Ning Zhang, Hongde XU, Liu Cao, Haipeng Zhang
Int. J. Biol. Sci. 2012; 8(5): 707-718. doi:10.7150/ijbs.4231
[Abstract] [Full text] [PDF]

Research Paper
Interactions of Several Lipid-Related Gene Polymorphisms and Cigarette Smoking on Blood Pressure Levels
Rui-Xing Yin, Dong-Feng Wu, Jin-Zhen Wu, Xiao-Li Cao, Lynn Htet Htet Aung, Lin Miao, Xing-Jiang Long, Wan-Ying Liu, Lin Zhang, Meng Li
Int. J. Biol. Sci. 2012; 8(5): 685-696. doi:10.7150/ijbs.4401
[Abstract] [Full text] [PDF]

Review
Surf the Post-translational Modification Network of p53 Regulation
Bo Gu, Wei-Guo Zhu
Int. J. Biol. Sci. 2012; 8(5): 672-684. doi:10.7150/ijbs.4283
[Abstract] [Full text] [PDF]

Review
Fibroblast Growth Factor-23 Helps Explain the Biphasic Cardiovascular Effects of Vitamin D in Chronic Kidney Disease
Peng Hu, Qiang Xuan, Bo Hu, Ling Lu, Jing Wang, Yuan Han Qin
Int. J. Biol. Sci. 2012; 8(5): 663-671. doi:10.7150/ijbs.3886
[Abstract] [Full text] [PDF]

Research Paper
Selection of Peptide Inhibitor to Matrix Metalloproteinase-2 Using Phage Display and Its Effects on Pancreatic Cancer Cell lines PANC-1 and CFPAC-1
Gao Lu, Maqing Zheng, Yunxia Zhu, Min Sha, Yue Wu, Xiao Han
Int. J. Biol. Sci. 2012; 8(5): 650-662. doi:10.7150/ijbs.3897
[Abstract] [Full text] [PDF]

Research Paper
Characterization of the Complete Mitochondrial Genome Sequence of Spirometra erinaceieuropaei (Cestoda: Diphyllobothriidae) from China
Guo-Hua Liu, Chun Li, Jia-Yuan Li, Dong-Hui Zhou, Rong-Chuan Xiong, Rui-Qing Lin, Feng-Cai Zou, Xing-Quan Zhu
Int. J. Biol. Sci. 2012; 8(5): 640-649. doi:10.7150/ijbs.4096
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Glycosylation of the Sodium Channel β4 Subunit is Developmentally Regulated and Involves in Neuritic Degeneration
Ting-ting Zhou, Zhen-wei Zhang, Jun Liu, Jian-peng Zhang, Bing-hua Jiao
Int. J. Biol. Sci. 2012; 8(5): 630-639. doi:10.7150/ijbs.3684
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Real-time Investigation of Measles Epidemics with Estimate of Vaccine Efficacy
Keisuke Ejima, Ryosuke Omori, Kazuyuki Aihara, Hiroshi Nishiura
Int. J. Biol. Sci. 2012; 8(5): 620-629. doi:10.7150/ijbs.4329
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Drosophila eyes absent is a Novel mRNA Target of the Tristetraprolin (TTP) Protein DTIS11
Po-An Yeh, Wen-Hsuan Yang, Pei-Yu Chiang, Shun-Chang Wang, Mau-Sun Chang, Ching-Jin Chang
Int. J. Biol. Sci. 2012; 8(5): 606-619. doi:10.7150/ijbs.3782
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
The Gain of Function of p53 Mutant p53S in Promoting Tumorigenesis by Cross-talking with H-RasV12
Shuting Jia, Lanjun Zhao, Wenru Tang, Ying Luo
Int. J. Biol. Sci. 2012; 8(5): 596-605. doi:10.7150/ijbs.4176
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Genome-Wide Association Analysis of Meat Quality Traits in a Porcine Large White × Minzhu Intercross Population
Weizhen Luo, Duxue Cheng, Shaokang Chen, Ligang Wang, Yong Li, Xiaojun Ma, Xin Song, Xin Liu, Wen Li, Jing Liang, Hua Yan, Kebin Zhao, Chuduan Wang, Lixian Wang, Longchao Zhang
Int. J. Biol. Sci. 2012; 8(4): 580-595. doi:10.7150/ijbs.3614
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Characterization of the Complete Mitochondrial Genomes of Cnaphalocrocis medinalis and Chilo suppressalis (Lepidoptera: Pyralidae)
Huan-Na Chai, Yu-Zhou Du, Bao-Ping Zhai
Int. J. Biol. Sci. 2012; 8(4): 561-579. doi:10.7150/ijbs.3540
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Data Mining in Networks of Differentially Expressed Genes during Sow Pregnancy
Ligang Wang, Longchao Zhang, Yong Li, Wen Li, Weizhen Luo, Duxue Cheng, Hua Yan, Xiaojun Ma, Xin Liu, Xin Song, Jing Liang, Kebin Zhao, Lixian Wang
Int. J. Biol. Sci. 2012; 8(4): 548-560. doi:10.7150/ijbs.4071
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Isoalantolactone Induces Reactive Oxygen Species Mediated Apoptosis in Pancreatic Carcinoma PANC-1 Cells
Muhammad Khan, Chuan Ding, Azhar Rasul, Fei Yi, Ting Li, Hongwen Gao, Rong Gao, Lili Zhong, Kun Zhang, Xuedong Fang, Tonghui Ma
Int. J. Biol. Sci. 2012; 8(4): 533-547. doi:10.7150/ijbs.3753
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
TWIST Represses Estrogen Receptor-alpha Expression by Recruiting the NuRD Protein Complex in Breast Cancer Cells
Junjiang Fu, Lianmei Zhang, Tao He, Xiuli Xiao, Xiaoyan Liu, Li Wang, Luquan Yang, Manman Yang, Tiandan Zhang, Rui Chen, Jianming Xu
Int. J. Biol. Sci. 2012; 8(4): 522-532. doi:10.7150/ijbs.4164
[Abstract] [Full text] [PDF] [PubMed] [PMC]

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