International Journal of Biological Sciences

International Journal of Medical Sciences

Editor-in-Chief: Chuxia Deng, PhD, National Institutes of Health*, Bethesda, MD
* Dr. Deng is serving in his personal capacity.
Editor-in-Chief's Profile

The latest impact factor of IJBS is 3.215, up from previous 2.865. This puts the journal in the top 15.4% of all SCI journals, up from previous 18.4%. Congratulation!
Indexed/covered by MEDLINE, PubMed, Science Citation Index (SCI) Expanded, Current Contents®/Life Sciences, EMBASE, CAS, CABI, Scopus (full index information)
Full texts of articles in PubMed Central, UK PMC, and PMC Canada.
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This Journal is ranked among the top 2.1% of journals (29/1380) according to SCImago in the area of Agricultural and Biological Sciences ...details

Top cited papers:

TM Thornton & M Rincon. Non-Classical P38 Map Kinase Functions: Cell Cycle Checkpoints and Survival. Cited by 80
HB Shao et al. Primary antioxidant free radical scavenging and redox signaling pathways in higher plant cells. Cited by 112
JK Lunney. Advances in Swine Biomedical Model Genomics. Cited by 122
DP Siderovski & FS Willard. The GAPs, GEFs, and GDIs of heterotrimeric G-protein alpha subunits. Cited by 138

Most Cited Paper Award: Winners of this year are Tina M. Thornton and Mercedes Rincon from University of Vermont, "Non-Classical P38 Map Kinase Functions: Cell Cycle Checkpoints and Survival ". Cited by 80. Winners of previous years were Hong-Bo Shao et al. "Primary antioxidant free radical scavenging and redox signaling pathways in higher plant cells", and Joan K. Lunney "Advances in Swine Biomedical Model Genomics". ...details

Pancreatitis occurs when digestive enzymes are activated in the pancreas. Severe pancreatitis has a 10-30% mortality rate. No specific treatments for pancreatitis exist now. Here, Feng et al. discovered that interleukin-22 (IL-22) may have therapeutic potential in treating acute and chronic pancreatitis. Wild-type and IL-22 knockout mice were equally susceptible to ceru-lein-induced acute and chronic pancreatitis, whereas liver-specific IL-22 transgenic mice were completely resistant to cerulein-induced elevation of serum digestive enzymes, pancreatic necrosis and apoptosis, and inflammatory cell infiltration. Treatment of wild-type mice with recombinant IL-22 or adenovirus IL-22 markedly attenuated the severity of cerulein-induced acute and chronic pancreatitis. ...details

Kaposi sarcoma-associated herpesvirus (KSHV) is a causative agent for Kaposi sarcoma and primary effusion lymphoma. KSHV encodes a viral ORF57 (also named Mta) to regulate viral gene expression by enhancing viral RNA splicing and stability. In this study, we identified viral PAN RNA, a long non-coding polyadenylated nuclear RNA, as a main target of ORF57 by a genome-wide CLIP (cross-linking and immunoprecipitation) approach. KSHV genome lacking ORF57 expresses only a minimal amount of PAN. In cell cotransfection, ORF57 increased PAN expression by 20-30-fold. ...details

Mouse protein tyrosine phosphatase PTPBR7 is a receptor-like, transmembrane protein that is localized on the surface of neuronal cells. Its protein phosphatase activity is reduced upon multimerization, and PTPBR7-deficient mice display motor coordination defects. Extracellular molecules that may influence PTPBR7 activity, however, remain to be determined. We here show that the PTPBR7 extracellular domain binds to highly myelinated regions in mouse brain, in particular the white matter tracks in cerebellum. PTPBR7 deficiency does not alter this binding pattern, as witnessed by RAP in situ staining of Ptprr^-/- mouse brain sections. ...details

Traditional wisdom holds that intact immune responses, such as immune surveillance or immunoediting, are required for preventing and inhibiting tumor development; but recent evidence has also indicated that unresolved immune responses, such as chronic inflammation, can promote the growth and progression of cancer. Within the immune system, cytotoxic CD8⁺ and CD4⁺ Th1 T cells, along with their characteristically produced cytokine IFN-γ, function as the major anti-tumor immune effector cells, whereas tumor associated macrophages (TAM) or myeloid-derived suppressive cells (MDSC) and their derived cytokines IL-6, TNF, IL-1β and IL-23 are generally recognized as dominant tumor-promoting forces. ...details

Signal transducer and activator of transcription 3 (STAT3) is a transcription factor that is activated by many cytokines and growth factors and plays a key role in cell survival, proliferation, and differentiation. STAT3 activation is detected virtually in all rodent models of liver injury and in human liver diseases. In this review, we highlight recent advances of STAT3 signaling in liver injury, steatosis, inflammation, regeneration, fibrosis, and hepatocarcinogenesis. The cytokines and small molecules that activate STAT3 in hepatocytes may have therapeutic benefits to treat acute liver injury, fatty liver disease, and alcoholic hepatitis, while blockage of STAT3 may have a therapeutic potential to prevent and treat liver cancer. ...details

IJBS issue cover

Short Research Communication
Activated β-catenin Forces N2A Cell-derived Neurons Back to Tumor-like Neuroblasts and Positively Correlates with a Risk for Human Neuroblastoma
Feng Zhi, Guangming Gong, Yan Xu, Yan Zhu, Die Hu, Yilin Yang, Yiqiao Hu
Int. J. Biol. Sci. 2012; 8(2): 289-297. doi:10.7150/ijbs.3520
[Abstract] [Full text] [PDF]

Review
TGF-β and BMP Signaling in Osteoblast Differentiation and Bone Formation
Guiqian Chen, Chuxia Deng, Yi-Ping Li
Int. J. Biol. Sci. 2012; 8(2): 272-288. doi:10.7150/ijbs.2929
[Abstract] [Full text] [PDF]

Research Paper
Measurement of Hepatic Protein Fractional Synthetic Rate with Stable Isotope Labeling Technique in Thapsigargin Stressed HepG2 Cells
Juquan Song, Xiao-jun Zhang, Darren Boehning, Natasha C. Brooks, David N. Herndon, Marc G. Jeschke
Int. J. Biol. Sci. 2012; 8(2): 265-271. doi:10.7150/ijbs.3660
[Abstract] [Full text] [PDF]

Mini-review
An Updated Nomenclature for Keratin-Associated Proteins (KAPs)
Hua Gong, Huitong Zhou, Grant W. McKenzie, Zhidong Yu, Stefan Clerens, Jolon M. Dyer, Jeffrey E. Plowman, Mathew W. Wright, Reena Arora, C. Simon Bawden, Yulin Chen, Jinquan Li, Jonathan G. H. Hickford
Int. J. Biol. Sci. 2012; 8(2): 258-264. doi:10.7150/ijbs.3278
[Abstract] [Full text] [PDF]

Research Paper
Interleukin-22 Ameliorates Cerulein-Induced Pancreatitis in Mice by Inhibiting the Autophagic Pathway
Dechun Feng, Ogyi Park, Svetlana Radaeva, Hua Wang, Shi Yin, Xiaoni Kong, Mingquan Zheng, Sam Zakhari, Jay K. Kolls, Bin Gao
Int. J. Biol. Sci. 2012; 8(2): 249-257. doi:10.7150/ijbs.3967
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Simvastatin Modulates Remodeling of Kv4.3 Expression in Rat Hypertrophied Cardiomyocytes
Feifei Su, Miaoqian Shi, Zhiqiang Yan, Dongbo Ou, Juntang Li, Zifan Lu, Qiangsun Zheng
Int. J. Biol. Sci. 2012; 8(2): 236-248. doi:10.7150/ijbs.8.236
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Review
The Pro-inflammatory Role of TGFβ1: A Paradox?
Gangwen Han, Fulun Li, Tej Pratap Singh, Peter Wolf, Xiao-Jing Wang
Int. J. Biol. Sci. 2012; 8(2): 228-235. doi:10.7150/ijbs.8.228
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Contrasting Cellularity and Fatty Acid Composition in Fat Depots from Alentejana and Barrosã Bovine Breeds Fed High and Low Forage Diets
Ana S.H. Costa, Paula A. Lopes, Marta Estevão, Susana V. Martins, Susana P. Alves, Rui M.A. Pinto, Hugo Pissarra, Jorge J. Correia, Mário Pinho, Carlos M.G.A. Fontes, José A.M. Prates
Int. J. Biol. Sci. 2012; 8(2): 214-227. doi:10.7150/ijbs.8.214
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Review
TGFβ Signaling and Cardiovascular Diseases
Evangelia Pardali, Peter ten Dijke
Int. J. Biol. Sci. 2012; 8(2): 195-213. doi:10.7150/ijbs.8.195
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Short Research Communication
The Adhesion Modulating Properties of Tenascin-W
Florence Brellier, Enrico Martina, Matthias Chiquet, Jacqueline Ferralli, Michael van der Heyden, Gertraud Orend, Johannes C. Schittny, Ruth Chiquet-Ehrismann, Richard P. Tucker
Int. J. Biol. Sci. 2012; 8(2): 187-194. doi:10.7150/ijbs.8.187
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
The Murine Caecal MicroRNA Signature Depends on the Presence of the Endogenous Microbiota
Natasha Singh, Elize A. Shirdel, Levi Waldron, Regan-Heng Zhang, Igor Jurisica, Elena M. Comelli
Int. J. Biol. Sci. 2012; 8(2): 171-186. doi:10.7150/ijbs.8.171
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
The Olfactory Co-receptor Orco from the Migratory Locust (Locusta migratoria) and the Desert Locust (Schistocerca gregaria): Identification and Expression pattern
Ying Yang, Jürgen Krieger, Long Zhang, Heinz Breer
Int. J. Biol. Sci. 2012; 8(2): 159-170. doi:10.7150/ijbs.8.159
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Matrine Inhibits Pacing Induced Atrial Fibrillation by Modulating I_KM3 and I_Ca-L
Yuhong Zhou, Wei Xu, Ruyi Han, Jiaying Zhou, Zhenwei Pan, Huo Rong, Junnan Li, Changqing Xu, Guofen Qiao, Yanjie Lu
Int. J. Biol. Sci. 2012; 8(1): 150-158. doi:10.7150/ijbs.8.150
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Altered Antioxidant Status and Increased Lipid Per-Oxidation in Seminal Plasma of Tunisian Infertile Men
Fatma Atig, Monia Raffa, Habib Ben Ali, Kerkeni Abdelhamid, Ali Saad, Mounir Ajina
Int. J. Biol. Sci. 2012; 8(1): 139-149. doi:10.7150/ijbs.8.139
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Molecular Cloning and Characterization of Ecdysone oxidase and 3-dehydroecdysone-3α-reductase Involved in the Ecdysone Inactivation Pathway of Silkworm, Bombyx mori
Wei Sun, Yi-Hong Shen, Deng-Wei Qi, Zhong-Huai Xiang, Ze Zhang
Int. J. Biol. Sci. 2012; 8(1): 125-138. doi:10.7150/ijbs.8.125
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Erratum
Correction: Molecular Characterization of Transcriptome-wide Interactions between Highly Pathogenic Porcine Reproductive and Respiratory Syndrome Virus and Porcine Alveolar Macrophages in vivo
Ping Zhou, Shanli Zhai, Xiang Zhou, Ping Lin, Tengfei Jiang, Xueying Hu, Yunbo Jiang, Bin Wu, Qingde Zhang, Xuewen Xu, Jin-ping Li, Bang Liu
Int. J. Biol. Sci. 2012; 8(1): 124. doi:10.7150/ijbs.8.124
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Immune-related MicroRNAs are Abundant in Breast Milk Exosomes
Qi Zhou, Mingzhou Li, Xiaoyan Wang, Qingzhi Li, Tao Wang, Qi Zhu, Xiaochuan Zhou, Xin Wang, Xiaolian Gao, Xuewei Li
Int. J. Biol. Sci. 2012; 8(1): 118-123. doi:10.7150/ijbs.8.118
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Identification of Ghrelin Receptor Blocker, D-[Lys3] GHRP-6 as a CXCR4 Receptor Antagonist
Kalpesh Patel, Vishwa Deep Dixit, Jun Ho Lee, Jie Wan Kim, Eric M. Schaffer, Dzung Nguyen, Dennis D. Taub
Int. J. Biol. Sci. 2012; 8(1): 108-117. doi:10.7150/ijbs.8.108
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
The Complete Mitochondrial Genome of the Damsel Bug Alloeorhynchus bakeri (Hemiptera: Nabidae)
Hu Li, Haiyu Liu, Liangming Cao, Aimin Shi, Hailin Yang, Wanzhi Cai
Int. J. Biol. Sci. 2012; 8(1): 93-107. doi:10.7150/ijbs.8.93
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
The Putative Metal Coordination Motif in the Endonuclease Domain of Human Parvovirus B19 NS1 Is Critical for NS1 Induced S Phase Arrest and DNA Damage
Violetta Kivovich, Leona Gilbert, Matti Vuento, Stanley J. Naides
Int. J. Biol. Sci. 2012; 8(1): 79-92. doi:10.7150/ijbs.8.79
[Abstract] [Full text] [PDF] [PubMed] [PMC]

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