International Journal of Medical Sciences
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This Journal is ranked among the top 2.1% of journals (29/1380) according to SCImago in the area of
Agricultural and Biological Sciences ...details
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| Vertebrate Hox genes regulate many aspects of embryonic body plan
development and patterning. In this study, Hostikka et al generated
mice carrying a targeted mutation of Hoxc10, a member of the Hox10
paralogous family. Their data revealed a role for Hoxc10 in
generating or maintaining the normal complement of lumbar motor neurons.
More ... |
| The promyelocytic leukemia protein (PML) is involved in many cellular
processes including cell cycle progression, DNA damage response,
transcriptional regulation, viral infection, and apoptosis. These
cellular activities often rely on the localization of PML to unique
subnuclear structures known as PML nuclear bodies (NBs). More than 50
cellular proteins are known to traffic in and out of PML NBs, either
transiently or constitutively. In order to understand the dynamics of
these NBs, it is important to delineate the regulation of PML itself.
PML is subject to extensive regulation at transcriptional, post-
transcriptional, and post-translational levels. Many of these modes
of regulation depend on the cellular context and the presence of
extracellular signals. Here Reineke and Kao reviewed the current
knowledge of regulation of PML under normal cellular conditions as
well as the role for regulation of PML in viral infection and cancer.
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| Pulmonary fibrosis is an intractable paranchymal lung disease
characterized by persistent alveolitis, accumulation of connective
tissue and extracellular matrix, Here, Dr. Inage et al. investigated
the potential usefulness of vesnarinone, a novel cytokine inhibitor,
for the treatment of lung fibrosis using a murine model of bleomycin
(BLM)-induced pulmonary fibrosis. Their data indicated that dietary
intake of vesnarinone minimized the BLM toxicity as reflected by
significant decreases in numbers of inflammatory cells, KC, and
soluble TNF receptors in the bronchoalveolar lavage fluid. A
quantitative evaluation of histology demonstrated significantly mild
lung parenchymal lesions in BLM-treated mice fed with diet containing
high dose of vesnarinone than in the control diet group. Consistent
with the histopathology, hydroxyproline levels in lung tissue from
BLM-treated mice fed with diet containing vesnarinone were
significantly lower than that from mice fed with control diet. We
concluded that vesnarinone inhibits BLM-induced pulmonary fibrosis,
at least in part, by the inhibition of acute lung injuries in the
early phase.
More ... |
| SIRT1 has been considered as a tumor promoter because of its increased expression in some types of cancers and its role in inactivating proteins that are involved in tumor suppression and DNA damage repair. However, recent studies demonstrated that SIRT1 levels are reduced in some other types of cancers, and that SIRT1 deficiency results in genetic instability and tumorigenesis, while overexpression of SIRT1 attenuates cancer formation in mice heterozygous for tumor suppressor p53 or APC. In this study, Deng reviewed these recent findings and discussed the possibility that activation of SIRT1 both extends lifespan and inhibits cancer formation. More ... |
Compared to mouse, rat is a superior model of human diseases. As technology advances in gene manipulation, a need for genetic rat models has been increasingly pursued. In this study, Zhou et al.
generated multiple lines of transgenic rats to express the tetracycline-controlled transactivator (tTA) gene for conditional gene regulation. Expression of the tTA transgene was sufficient to vigorously and ubiquitously activate its reporter gene. Dynamics of doxycycline-regulated gene expression was thoroughly assessed for the first time in rats. For a quick switch between the ON and OFF statuses of tTA-activated gene expression, a complex regime of doxycycline administration was developed: doxycycline was administered at a high dose (500ug/ml) for two days to reach the effective concentration and was then switched to a low dose (20ug/ml) to maintain the effectiveness. Thus, these tTA transgenic lines should be valuable for the development of genetic rat models for human diseases. ... more
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| The BP1 (Beta Protein 1) gene is overexpressed in 81% of primary
breast cancer and its expression is closely correlated with the
progression of breast cancer. In this study, Song et al used the
chromatin immunoprecipitation on chip (ChIP-on-chip) and gene
expression microarray assays to identify candidate target genes and
gene networks, which are directly regulated by BP1 in ER negative
breast cancer cells. After rigorous bioinformatic and statistical
analysis for both ChIP-on-chip and expression microarray gene lists,
18 overlapping genes were noted and verified. Those potential target
genes are involved in a variety of tumorigenic pathways, which sheds
light on the functional mechanisms of BP1 in breast cancer
development and progression. ... more |
In Celebration of Dr. Mario R. Capecchi's Nobel Prize:
This year, the Nobel Prize in Physiology or Medicine goes to Drs. Mario R. Capecchi, Martin J. Evans and Oliver Smithies for their discoveries of principles for introducing specific gene modifications in mice by the use of embryonic stem (ES) cells. This technology, commonly referred to as gene targeting or knockout, is based on homologous recombination between DNA sequences residing in the chromosome and newly introduced DNA to mutate any genes of interesting in mouse genome. ...more |
The winners of 2005 Most Cited Paper Award were Ashley C. Bibby and David W. Litchfield, who were issued a certificate together with a cash prize. The winners of 2006 Most Cited Paper Award were JA De Soto, X Wang, Y Tominaga, et al. Details ... |
A peer-reviewed journal publishes articles of significance in all areas of biological sciences in the forms of original research papers, reviews and short research communications.
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Axial and appendicular skeletal transformations, ligament alterations, and motor neuron loss in Hoxc10 mutants
Sirkka Liisa Hostikka, Jun Gong, Ellen M. Carpenter
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BMP13 Prevents the Effects of Annular Injury in an Ovine Model
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Mohamed F Ismail, Doaa A Ali, Augusta Fernando, Mohamed E Abdraboh, Rajiv L Gaur, Wael M Ibrahim, Madhwa HG Raj, Allal Ouhtit
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Targeting Promyelocytic Leukemia Protein: A Means to Regulating PML Nuclear Bodies
Erin L. Reineke, Hung-Ying Kao
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Characterization of the complete mitochondrial genome of the giant silkworm moth, Eriogyna pyretorum (Lepidoptera: Saturniidae)
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