Int J Biol Sci
2011; 7(6):700-707.
doi:10.7150/ijbs.7.700 This issueCite
Research Paper
Modeling the Effects of a Simple Immune System and Immunodeficiency on the Dynamics of Conjointly Growing Tumor and Normal Cells
Mitra Shojania Feizabadi1 ✉, Tarynn M. Witten2
1. Physics Department, Seton Hall University, South Orange, NJ 07079, USA 2. Center for the Study of Biological Complexity, PO Box 842030, Virginia Commonwealth University, Richmond, VA 23284-2030, USA
✉ Corresponding author: Mitra Shojania Feizabadi, Physics Department, Seton Hall University, 400 South Orange Ave, South Orange, NJ 07079, Phone: 973-761-9403, Email: shojanmiedu
Citation:
Feizabadi MS, Witten TM. Modeling the Effects of a Simple Immune System and Immunodeficiency on the Dynamics of Conjointly Growing Tumor and Normal Cells. Int J Biol Sci 2011; 7(6):700-707. doi:10.7150/ijbs.7.700. https://www.ijbs.com/v07p0700.htm
In this paper, we develop a theoretical contribution towards the understanding of the complex behavior of conjoint tumor-normal cell growth under the influence of immuno-chemotheraputic agents under simple immune system response. In particular, we consider a core model for the interaction of tumor cells with the surrounding normal cells. We then add the effects of a simple immune system, and both immune-suppression factors and immuno-chemotherapeutic agents as well. Through a series of numerical simulations, we illustrate that the interdependency of tumor-normal cells, together with choice of drug and the nature of the immunodeficiency, leads to a variety of interesting patterns in the evolution of both the tumor and the normal cell populations.
Feizabadi, M.S., Witten, T.M. (2011). Modeling the Effects of a Simple Immune System and Immunodeficiency on the Dynamics of Conjointly Growing Tumor and Normal Cells. International Journal of Biological Sciences, 7(6), 700-707. https://doi.org/10.7150/ijbs.7.700.
ACS
Feizabadi, M.S.; Witten, T.M. Modeling the Effects of a Simple Immune System and Immunodeficiency on the Dynamics of Conjointly Growing Tumor and Normal Cells. Int. J. Biol. Sci. 2011, 7 (6), 700-707. DOI: 10.7150/ijbs.7.700.
NLM
Feizabadi MS, Witten TM. Modeling the Effects of a Simple Immune System and Immunodeficiency on the Dynamics of Conjointly Growing Tumor and Normal Cells. Int J Biol Sci 2011; 7(6):700-707. doi:10.7150/ijbs.7.700. https://www.ijbs.com/v07p0700.htm
CSE
Feizabadi MS, Witten TM. 2011. Modeling the Effects of a Simple Immune System and Immunodeficiency on the Dynamics of Conjointly Growing Tumor and Normal Cells. Int J Biol Sci. 7(6):700-707.