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Int J Biol Sci 2023; 19(15):4915-4930. doi:10.7150/ijbs.86039 This issue Cite

Review

The emerging roles of metabolism in the crosstalk between breast cancer cells and tumor-associated macrophages

Yuxin Liang1,2, Jun He3, Xiguang Chen1, Liyang Yin1, Qiong Yuan1,2, Qiting Zeng1,2, Xuyu Zu1✉, Yingying Shen1✉

1. Cancer Research Institute, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan 421001, China.
2. Department of Clinical Laboratory Medicine, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan, 421001, China.
3. Department of Spine Surgery, The Nanhua Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, China.

✉ Corresponding authors: Yingying Shen; Xuyu Zu; Tel: +86 18175887441; +86-0734-8279382; E-mail: shenyy3sysu.edu.cn; 2019000092edu.cn.

Citation:
Liang Y, He J, Chen X, Yin L, Yuan Q, Zeng Q, Zu X, Shen Y. The emerging roles of metabolism in the crosstalk between breast cancer cells and tumor-associated macrophages. Int J Biol Sci 2023; 19(15):4915-4930. doi:10.7150/ijbs.86039. https://www.ijbs.com/v19p4915.htm
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Abstract

Graphic abstract

Breast cancer is the most common cancer affecting women worldwide. Investigating metabolism in breast cancer may accelerate the exploitation of new therapeutic options for immunotherapies. Metabolic reprogramming can confer breast cancer cells (BCCs) with a survival advantage in the tumor microenvironment (TME) and metabolic alterations in breast cancer, and the corresponding metabolic byproducts can affect the function of tumor-associated macrophages (TAMs). Additionally, TAMs undergo metabolic reprogramming in response to signals present in the TME, which can affect their function and breast cancer progression. Here, we review the metabolic crosstalk between BCCs and TAMs in terms of glucose, lipids, amino acids, iron, and adenosine metabolism. Summaries of inhibitors that target metabolism-related processes in BCCs or TAMs within breast cancer have also served as valuable inspiration for novel therapeutic approaches in the fight against this disease. This review provides new perspectives on targeted anticancer therapies for breast cancer that combine immunity with metabolism.

Keywords: breast cancer, tumor-associated macrophages, metabolism, crosstalk, targeted therapy

Citation styles

APA
Liang, Y., He, J., Chen, X., Yin, L., Yuan, Q., Zeng, Q., Zu, X., Shen, Y. (2023). The emerging roles of metabolism in the crosstalk between breast cancer cells and tumor-associated macrophages. International Journal of Biological Sciences, 19(15), 4915-4930. https://doi.org/10.7150/ijbs.86039.

ACS
Liang, Y.; He, J.; Chen, X.; Yin, L.; Yuan, Q.; Zeng, Q.; Zu, X.; Shen, Y. The emerging roles of metabolism in the crosstalk between breast cancer cells and tumor-associated macrophages. Int. J. Biol. Sci. 2023, 19 (15), 4915-4930. DOI: 10.7150/ijbs.86039.

NLM
Liang Y, He J, Chen X, Yin L, Yuan Q, Zeng Q, Zu X, Shen Y. The emerging roles of metabolism in the crosstalk between breast cancer cells and tumor-associated macrophages. Int J Biol Sci 2023; 19(15):4915-4930. doi:10.7150/ijbs.86039. https://www.ijbs.com/v19p4915.htm

CSE
Liang Y, He J, Chen X, Yin L, Yuan Q, Zeng Q, Zu X, Shen Y. 2023. The emerging roles of metabolism in the crosstalk between breast cancer cells and tumor-associated macrophages. Int J Biol Sci. 19(15):4915-4930.

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