Epigenetic modulations of immune cells: from normal development to tumor progression

Xu, Yuanchun; He, Zongsheng; Du, Jing; Chen, Ziqiang; Creemers, John W. M.; Wang, Bin; Li, Fan; Wang, Yaling

doi:10.7150/ijbs.88327

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Theranostics

International Journal of Medical Sciences

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Journal of Cancer

Journal of Genomics

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Int J Biol Sci 2023; 19(16):5120-5144. doi:10.7150/ijbs.88327 This issue Cite

Review

Epigenetic modulations of immune cells: from normal development to tumor progression

Yuanchun Xu^1,4*, Zongsheng He^2*, Jing Du¹, Ziqiang Chen¹, John W. M. Creemers³, Bin Wang^2✉, Fan Li^1✉, Yaling Wang^4✉

1. Department of General Surgery, Daping Hospital, Army Medical University, Chongqing, China.
2. Department of Gastroenterology, Daping Hospital, Army Medical University, Chongqing, China.
3. Department of Human Genetics, KU Leuven, Leuven, Belgium.
4. Department of nursing, Daping Hospital, Army Medical University, Chongqing, China.
*,^✉ Contributed equally

Citation:

Xu Y, He Z, Du J, Chen Z, Creemers JWM, Wang B, Li F, Wang Y. Epigenetic modulations of immune cells: from normal development to tumor progression. Int J Biol Sci 2023; 19(16):5120-5144. doi:10.7150/ijbs.88327. https://www.ijbs.com/v19p5120.htm

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Abstract

The dysfunction of immune cell development often impairs immunological homeostasis, thus causing various human diseases. Accumulating evidence shows that the development of different immune cells from hematopoietic stem cells are highly fine-tuned by different epigenetic mechanisms including DNA methylation, histone modifications, chromatin remodeling and RNA-related regulations. Understanding how epigenetic regulators modulate normal development of immune cells contributes to the identification of new strategies for various diseases. Here, we review recent advances suggesting that epigenetic modulations can orchestrate immune cell development and functions through their impact on critical gene expression. We also discuss the aberrations of epigenetic modulations in immune cells that influence tumor progression, and the fact that underlying mechanisms affect how epigenetic drugs interfere with tumor progression in the clinic.

Keywords: Innate immune cells, adaptive immune cells, DNA methylation, histone modifications, chromatin remodeling, RNA-associated modulations, cancer treatment

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APA

Xu, Y., He, Z., Du, J., Chen, Z., Creemers, J.W.M., Wang, B., Li, F., Wang, Y. (2023). Epigenetic modulations of immune cells: from normal development to tumor progression. International Journal of Biological Sciences, 19(16), 5120-5144. https://doi.org/10.7150/ijbs.88327.

ACS

Xu, Y.; He, Z.; Du, J.; Chen, Z.; Creemers, J.W.M.; Wang, B.; Li, F.; Wang, Y. Epigenetic modulations of immune cells: from normal development to tumor progression. Int. J. Biol. Sci. 2023, 19 (16), 5120-5144. DOI: 10.7150/ijbs.88327.

NLM

CSE

Xu Y, He Z, Du J, Chen Z, Creemers JWM, Wang B, Li F, Wang Y. 2023. Epigenetic modulations of immune cells: from normal development to tumor progression. Int J Biol Sci. 19(16):5120-5144.

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