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Int J Biol Sci 2023; 19(16):5160-5173. doi:10.7150/ijbs.86207 This issue Cite

Research Paper

Targeting Aquaporin-3 Attenuates Skin Inflammation in Rosacea

Mengting Chen1,2,3, Qinqin Peng1,2,3, Zixin Tan1,2,3, San Xu1,2,3, Yunying Wang1,2,3, Aike Wu1,2,3, Wenqin Xiao1,2,3, Qian Wang4, Hongfu Xie1,2,3, Ji Li1,2,3✉, Wei Shi1,2,3✉, Zhili Deng1,2,3✉

1. Department of Dermatology, Xiangya Hospital, Central South University, Changsha, China.
2. Hunan Key Laboratory of Aging Biology, Xiangya Hospital, Central South University, Changsha, China.
3. National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China.
4. Hunan Binsis Biotechnology Co., Ltd, Changsha, China.

✉ Corresponding authors: Zhili Deng, Wei Shi, or Ji Li, Department of Dermatology, Xiangya Hospital, Central South University, Changsha, China. E-mail: dengzhiliedu.cn (ZD); shiweiedu.cn (WS); liji_xyedu.cn (JL).

Citation:
Chen M, Peng Q, Tan Z, Xu S, Wang Y, Wu A, Xiao W, Wang Q, Xie H, Li J, Shi W, Deng Z. Targeting Aquaporin-3 Attenuates Skin Inflammation in Rosacea. Int J Biol Sci 2023; 19(16):5160-5173. doi:10.7150/ijbs.86207. https://www.ijbs.com/v19p5160.htm
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Abstract

Graphic abstract

Rosacea is a common inflammatory skin disorder mediated by the dysregulation of both keratinocytes and T cells. Here, we report that aquaporin 3 (AQP3), a channel protein that mediates the transport of water/glycerol, was highly expressed in the epidermis and CD4+ T cells of both rosacea patients and experimental mice. Specifically, AQP3 deletion blocked the development of rosacea-like skin inflammation in model mice with LL37-induced rosacea-like disease. We also present mechanistic evidence showing that AQP3 was essential to the activation of NF-κB signaling and subsequent production of disease-characteristic chemokines in keratinocytes. Moreover, we show that AQP3 was upregulated during T cell differentiation and promotes helper T (Th) 17 differentiation possibly via the activation of STAT3 signaling. Our findings reveal that AQP3-mediated activation of NF-κB in keratinocytes and activation of STAT3 in CD4+ T cells acted synergistically and contributed to the inflammation in rosacea.

Keywords: Rosacea, AQP3, Skin inflammation, NF-κB signaling, Th17 cell differentiation

Citation styles

APA
Chen, M., Peng, Q., Tan, Z., Xu, S., Wang, Y., Wu, A., Xiao, W., Wang, Q., Xie, H., Li, J., Shi, W., Deng, Z. (2023). Targeting Aquaporin-3 Attenuates Skin Inflammation in Rosacea. International Journal of Biological Sciences, 19(16), 5160-5173. https://doi.org/10.7150/ijbs.86207.

ACS
Chen, M.; Peng, Q.; Tan, Z.; Xu, S.; Wang, Y.; Wu, A.; Xiao, W.; Wang, Q.; Xie, H.; Li, J.; Shi, W.; Deng, Z. Targeting Aquaporin-3 Attenuates Skin Inflammation in Rosacea. Int. J. Biol. Sci. 2023, 19 (16), 5160-5173. DOI: 10.7150/ijbs.86207.

NLM
Chen M, Peng Q, Tan Z, Xu S, Wang Y, Wu A, Xiao W, Wang Q, Xie H, Li J, Shi W, Deng Z. Targeting Aquaporin-3 Attenuates Skin Inflammation in Rosacea. Int J Biol Sci 2023; 19(16):5160-5173. doi:10.7150/ijbs.86207. https://www.ijbs.com/v19p5160.htm

CSE
Chen M, Peng Q, Tan Z, Xu S, Wang Y, Wu A, Xiao W, Wang Q, Xie H, Li J, Shi W, Deng Z. 2023. Targeting Aquaporin-3 Attenuates Skin Inflammation in Rosacea. Int J Biol Sci. 19(16):5160-5173.

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