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Int J Biol Sci 2024; 20(4):1332-1355. doi:10.7150/ijbs.90982 This issue Cite

Review

Polyphenols Targeting NF-κB Pathway in Neurological Disorders: What We Know So Far?

Abdullah Al Mamun1,2, Chuxiao Shao1, Peiwu Geng1, Shuanghua Wang1, Jian Xiao1,2,3✉

1. Central Laboratory of The Sixth Affiliated Hospital of Wenzhou Medical University, Lishui People's Hospital, Lishui City, Zhejiang 323000, China.
2. Molecular Pharmacology Research Center, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou 325000, China.
3. Department of Wound Healing, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China.

✉ Corresponding author: Professor Jian Xiao (Email: xjianedu.cn; Orchid ID: http://orcid.org/0000-0001-7374-6506).

Citation:
Mamun AA, Shao C, Geng P, Wang S, Xiao J. Polyphenols Targeting NF-κB Pathway in Neurological Disorders: What We Know So Far?. Int J Biol Sci 2024; 20(4):1332-1355. doi:10.7150/ijbs.90982. https://www.ijbs.com/v20p1332.htm
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Abstract

Graphic abstract

Polyphenolic compounds have shown promising neuroprotective properties, making them a valuable resource for identifying prospective drug candidates to treat several neurological disorders (NDs). Numerous studies have reported that polyphenols can disrupt the nuclear factor kappa B(NF-κB) pathway by inhibiting the phosphorylation or ubiquitination of signaling molecules, which further prevents the degradation of IκB. Additionally, they prevent NF-κB translocation to the nucleus and pro-inflammatory cytokine production. Polyphenols such as curcumin, resveratrol, and pterostilbene had significant inhibitory effects on NF-κB, making them promising candidates for treating NDs. Recent experimental findings suggest that polyphenols possess a wide range of pharmacological properties. Notably, much attention has been directed towards their potential therapeutic effects in NDs such as Alzheimer's disease (AD), Parkinson's disease (PD), cerebral ischemia, anxiety, depression, autism, and spinal cord injury (SCI). Much preclinical data supporting the neurotherapeutic benefits of polyphenols has been developed. Nevertheless, this study has described the significance of polyphenols as potential neurotherapeutic agents, specifically emphasizing their impact on the NF-κB pathway. This article offers a comprehensive analysis of the involvement of polyphenols in NDs, including both preclinical and clinical perspectives.

Keywords: Polyphenols, NF-κB pathway, neurological disorders, Neuroinflammation, Alzheimer's disease, Parkinson's disease, spinal cord injury

Citation styles

APA
Mamun, A.A., Shao, C., Geng, P., Wang, S., Xiao, J. (2024). Polyphenols Targeting NF-κB Pathway in Neurological Disorders: What We Know So Far?. International Journal of Biological Sciences, 20(4), 1332-1355. https://doi.org/10.7150/ijbs.90982.

ACS
Mamun, A.A.; Shao, C.; Geng, P.; Wang, S.; Xiao, J. Polyphenols Targeting NF-κB Pathway in Neurological Disorders: What We Know So Far?. Int. J. Biol. Sci. 2024, 20 (4), 1332-1355. DOI: 10.7150/ijbs.90982.

NLM
Mamun AA, Shao C, Geng P, Wang S, Xiao J. Polyphenols Targeting NF-κB Pathway in Neurological Disorders: What We Know So Far?. Int J Biol Sci 2024; 20(4):1332-1355. doi:10.7150/ijbs.90982. https://www.ijbs.com/v20p1332.htm

CSE
Mamun AA, Shao C, Geng P, Wang S, Xiao J. 2024. Polyphenols Targeting NF-κB Pathway in Neurological Disorders: What We Know So Far?. Int J Biol Sci. 20(4):1332-1355.

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