Int J Biol Sci
2024; 20(6):2261-2263.
doi:10.7150/ijbs.91108 This issueCite
Hypothesis
A putative role for lactate in the crosstalk between chemokines and glycolysis in solid cancer
Selma Rivas-Fuentes1✉, Teresa Santos-Mendoza1, Alfonso Salgado-Aguayo2
1. Laboratory of Transcriptomics and Molecular Immunology, Instituto Nacional de Enfermedades Respiratorias “Ismael Cosío Villegas”, Mexico City, Mexico 2. Laboratory of Research on Rheumatic Diseases, Instituto Nacional de Enfermedades Respiratorias “Ismael Cosío Villegas”, Mexico City, Mexico
✉ Corresponding author: Laboratory of Transcriptomics and Molecular Immunology, Instituto Nacional de Enfermedades Respiratorias “Ismael Cosío Villegas”. Calzada de Tlalpan 4502, Tlalpan, Ciudad de México, D.F. 14080, México. Phone +52 (55) 5487 1700; E-mail: selma.rivasgob.mxMore
Citation:
Rivas-Fuentes S, Santos-Mendoza T, Salgado-Aguayo A. A putative role for lactate in the crosstalk between chemokines and glycolysis in solid cancer. Int J Biol Sci 2024; 20(6):2261-2263. doi:10.7150/ijbs.91108. https://www.ijbs.com/v20p2261.htm
Chemokines are very important for carcinogenesis and the development of a malignant phenotype. Lactate is a small molecule produced during glycolysis; recently it has emerged as an immunomodulator that could impact tumor cell behavior. In this paper we explore the interplay between chemokines, glycolysis, and lactate in cancer progression, and propose the existence of a pro-tumoral lactate-chemokine-glycolysis loop driven by high glucose levels.
Keywords: cancer, chemokines, glycolysis, lactate
Citation styles
APA
Rivas-Fuentes, S., Santos-Mendoza, T., Salgado-Aguayo, A. (2024). A putative role for lactate in the crosstalk between chemokines and glycolysis in solid cancer. International Journal of Biological Sciences, 20(6), 2261-2263. https://doi.org/10.7150/ijbs.91108.
ACS
Rivas-Fuentes, S.; Santos-Mendoza, T.; Salgado-Aguayo, A. A putative role for lactate in the crosstalk between chemokines and glycolysis in solid cancer. Int. J. Biol. Sci. 2024, 20 (6), 2261-2263. DOI: 10.7150/ijbs.91108.
NLM
Rivas-Fuentes S, Santos-Mendoza T, Salgado-Aguayo A. A putative role for lactate in the crosstalk between chemokines and glycolysis in solid cancer. Int J Biol Sci 2024; 20(6):2261-2263. doi:10.7150/ijbs.91108. https://www.ijbs.com/v20p2261.htm
CSE
Rivas-Fuentes S, Santos-Mendoza T, Salgado-Aguayo A. 2024. A putative role for lactate in the crosstalk between chemokines and glycolysis in solid cancer. Int J Biol Sci. 20(6):2261-2263.
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