Volume 20, Issue 7

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Global reach, higher impact

Volume 20 (7); 2024

Research Papers

Uncovering a Novel Functional Interaction Between Adult Hepatic Progenitor Cells, Inflammation and EGFR Signaling During Bile Acids-Induced Injury
Juan García-Sáez, María Figueroa-Fuentes, Carlos González-Corralejo, Cesáreo Roncero, Nerea Lazcanoiturburu, Álvaro Gutiérrez-Uzquiza, Javier Vaquero, Ester González-Sánchez, Kunzangla Bhutia, Silvia Calero-Pérez, Flavio Maina, Javier Traba, Ángela M. Valverde, Isabel Fabregat, Blanca Herrera, Aránzazu Sánchez
Int. J. Biol. Sci. 2024; 20(7): 2339-2355. doi:10.7150/ijbs.90645
Abstract Full text PDF

The dysadherin/FAK axis promotes individual cell migration in colon cancer
Choong-Jae Lee, Tae-Young Jang, Jee-Heun Kim, Songwon Lim, Sunjae Lee, Jeong-Seok Nam
Int. J. Biol. Sci. 2024; 20(7): 2356-2369. doi:10.7150/ijbs.86699
Abstract Full text PDF

Dysfunction of STING Autophagy Degradation in Senescent Nucleus Pulposus Cells Accelerates Intervertebral Disc Degeneration
Zhiqian Chen, Chen Chen, Xiao Yang, Yifan Zhou, Xiankun Cao, Chen Han, Tangjun Zhou, Jie Zhao, An Qin
Int. J. Biol. Sci. 2024; 20(7): 2370-2387. doi:10.7150/ijbs.88534
Abstract Full text PDF

Cancer-derived exosomal lncRNA SNHG3 promotes the metastasis of colorectal cancer through hnRNPC-mediating RNA stability of β-catenin
Ling Huang, Guang Yang, Yanfei Shao, Jing Sun, Xiao Yang, Hiju Hong, Batuer Aikemu, Galiya Yesseyeva, Shuchun Li, Chengsheng Ding, Xiaodong Fan, Sen Zhang, Junjun Ma, Minhua Zheng
Int. J. Biol. Sci. 2024; 20(7): 2388-2402. doi:10.7150/ijbs.88313
Abstract Full text PDF

Ciliogenesis-associated Kinase 1 Promotes Breast Cancer Cell Proliferation and Chemoresistance via Phosphorylating ERK1
Yanling He, Xinyuan Zhang, Weijun Pan, Jiebiao Zhang, Weiliang Zhu, Jian Zhang, Jian Shi
Int. J. Biol. Sci. 2024; 20(7): 2403-2421. doi:10.7150/ijbs.87442
Abstract Full text PDF

Oxidative stress promotes liver fibrosis by modulating the microRNA-144 and SIN3A-p38 pathways in hepatic stellate cells
Yawen Hao, Shaohua Song, Tao Li, Qiuhong Zai, Ningning Ma, Yixin Li, Liu Yang, Peng Xiao, Tianyue Xu, Longshan Ji, Jiaxin Tan, Yeni Ait Ahmed, Xiaogang Xiang, Xiaolin Wang, Fouad Lafdil, Qing Xie, Yong He
Int. J. Biol. Sci. 2024; 20(7): 2422-2439. doi:10.7150/ijbs.92749
Abstract Full text PDF

TSPAN6 reinforces the malignant progression of glioblastoma via interacting with CDK5RAP3 and regulating STAT3 signaling pathway
Chong Zhang, Fei-hua Du, Rou-xin Wang, Wen-bo Han, Xing Lv, Guo-qing Chen
Int. J. Biol. Sci. 2024; 20(7): 2440-2453. doi:10.7150/ijbs.85984
Abstract Full text PDF

Paris saponin VII reverses resistance to PARP inhibitors by regulating ovarian cancer tumor angiogenesis and glycolysis through the RORα/ECM1/VEGFR2 signaling axis
Mengfei Wang, Chenyue Yuan, Zong Wu, Meng Xu, Ziqi Chen, Jialiang Yao, Zujun Que, Jianhui Tian, Elaine Lai-Han Leung, Ziliang Wang
Int. J. Biol. Sci. 2024; 20(7): 2454-2475. doi:10.7150/ijbs.91861
Abstract Full text PDF

Muscularis macrophages controlled by NLRP3 maintain the homeostasis of excitatory neurons
Yunhuan Gao, Yi Shi, Ming Wei, Xiaorong Yang, Yang Hao, Haifeng Liu, Yuan Zhang, Lu Zhou, Gang Hu, Rongcun Yang
Int. J. Biol. Sci. 2024; 20(7): 2476-2490. doi:10.7150/ijbs.91389
Abstract Full text PDF

The Effect Mechanism of N6-adenosine Methylation (m6A) in Melatonin Regulated LPS-induced Colon Inflammation
Yuanyuan Li, Baochen Ma, Zixu Wang, Yaoxing Chen, Yulan Dong
Int. J. Biol. Sci. 2024; 20(7): 2491-2506. doi:10.7150/ijbs.95316
Abstract Full text PDF

Neuropeptide substance P attenuates colitis by suppressing inflammation and ferroptosis via the cGAS-STING signaling pathway
Jing Lan, Ziteng Deng, Qiuzhen Wang, Dan Li, Kai Fan, Jianyu Chang, Yunfei Ma
Int. J. Biol. Sci. 2024; 20(7): 2507-2531. doi:10.7150/ijbs.94548
Abstract Full text PDF

Aberrant Expression of SLC7A11 Impairs the Antimicrobial Activities of Macrophages in Staphylococcus Aureus Osteomyelitis in Mice
Bingsheng Yang, Wen Shu, Jin Hu, Zhongwen Wang, Jichang Wu, Jianwen Su, Jianye Tan, Bin Yu, Xianrong Zhang
Int. J. Biol. Sci. 2024; 20(7): 2555-2575. doi:10.7150/ijbs.93592
Abstract Full text PDF

Mitochondrial outer membrane protein MTUS1/ATIP1 exerts antitumor effects through ROS-induced mitochondrial pyroptosis in head and neck squamous cell carcinoma
Dongxiao Tang, Luodan Zhao, Shuojin Huang, Wuguo Li, Qianting He, Anxun Wang
Int. J. Biol. Sci. 2024; 20(7): 2576-2591. doi:10.7150/ijbs.94795
Abstract Full text PDF

TAZ deficiency impairs the autophagy-lysosomal pathway through NRF2 dysregulation and lysosomal dysfunction
Hyo Kyeong Kim, Hana Jeong, Mi Gyeong Jeong, Hee Yeon Won, Gibbeum Lee, Soo Han Bae, Miso Nam, Sung Hoon Lee, Geum-Sook Hwang, Eun Sook Hwang
Int. J. Biol. Sci. 2024; 20(7): 2592-2606. doi:10.7150/ijbs.88897
Abstract Full text PDF

Ferroptosis inhibitor alleviates sorafenib-induced cardiotoxicity by attenuating KLF11-mediated FSP1-dependent ferroptosis
Yilan Li, Jingru Yan, Heng Sun, Yating Liang, Qianqian Zhao, Shan Yu, Yao Zhang
Int. J. Biol. Sci. 2024; 20(7): 2622-2639. doi:10.7150/ijbs.86479
Abstract Full text PDF

HMGA1 sensitizes esophageal squamous cell carcinoma to mTOR inhibitors through the ETS1-FKBP12 axis
Jin-Rong Guo, Kai-Yue He, Jia-Li Yuan, Wang An, Wei-Tao Yin, Qiu-Tong Li, Li-Yuan Lu, Jing-Yu Yang, Meng-Jie Liu, Yu-Jia Li, Yuan Zhao, Qi Yang, Xin-Yuan Lei, Fan Gao, Lei Zhang, Dan-Hui Wu, Jun-Qi Li, Zi-Long Zhao, Huai Liu, Ling-Jun Zhu, Xiong-Yan Xiang, Qian-Hui Sun, Yong-Ping Jian, Zhi-Xiang Xu
Int. J. Biol. Sci. 2024; 20(7): 2640-2657. doi:10.7150/ijbs.95595
Abstract Full text PDF

Mitochondrial Dysfunction by FADDosome Promotes Gastric Mucosal Injury in Portal Hypertensive Gastropathy
Yuelin Xiao, Yiwang Zhang, Kaiduan Xie, Xiaoli Huang, Xianzhi Liu, Jinni Luo, Siwei Tan
Int. J. Biol. Sci. 2024; 20(7): 2658-2685. doi:10.7150/ijbs.90835
Abstract Full text PDF

E3 ubiquitin ligase BCA2 promotes breast cancer stemness by up-regulation of SOX9 by LPS
Min Zheng, Wenjing Liu, Rou Zhang, Dewei Jiang, Yujie Shi, Yingying Wu, Fei Ge, Ceshi Chen
Int. J. Biol. Sci. 2024; 20(7): 2686-2697. doi:10.7150/ijbs.92338
Abstract Full text PDF

Interstitial Fluid Shear Stress Induces the Synthetic Phenotype Switching of VSMCs to Release Pro-calcified Extracellular Vesicles via EGFR-MAPK-KLF5 Pathway
Wenbo Gao, Kaiyun Gu, Lunjie Ma, Fan Yang, Li Deng, Yaojia Zhang, Michael Z. Miao, Wenjun Li, Gang Li, Hong Qian, Zhen Zhang, Guixue Wang, Hongchi Yu, Xiaoheng Liu
Int. J. Biol. Sci. 2024; 20(7): 2727-2747. doi:10.7150/ijbs.90725
Abstract Full text PDF

Nuclear Softness Promotes the Metastatic Potential of Large-Nucleated Colorectal Cancer Cells via the ErbB4-Akt1-Lamin A/C Signaling Pathway
Yangkun Li, Qilin Li, Lei Mu, Yibing Hu, Chang Yan, Hui Zhao, Yulong Mi, Xiaolan Li, Deding Tao, Jichao Qin
Int. J. Biol. Sci. 2024; 20(7): 2748-2762. doi:10.7150/ijbs.89481
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Reviews

Autophagy in Its (Proper) Context: Molecular Basis, Biological Relevance, Pharmacological Modulation, and Lifestyle Medicine
Miguel A Ortega, Oscar Fraile-Martinez, Diego de Leon-Oliva, Diego Liviu Boaru, Laura Lopez-Gonzalez, Cielo García-Montero, Miguel Angel Alvarez-Mon, Luis G Guijarro, Diego Torres-Carranza, Miguel A Saez, Raul Diaz-Pedrero, Agustin Albillos, Melchor Alvarez-Mon
Int. J. Biol. Sci. 2024; 20(7): 2532-2554. doi:10.7150/ijbs.95122
Abstract Full text PDF

Glycosylation Targeting: A Paradigm Shift in Cancer Immunotherapy
Xueting Ren, Shuai Lin, Feng Guan, Huafeng Kang
Int. J. Biol. Sci. 2024; 20(7): 2607-2621. doi:10.7150/ijbs.93806
Abstract Full text PDF

LncRNAs as nodes for the cross-talk between autophagy and Wnt signaling in pancreatic cancer drug resistance
Yuhan Huang, Rui Zhang, Hao Lyu, Shuai Xiao, Dong Guo, Xing-Zhen Chen, Cefan Zhou, Jingfeng Tang
Int. J. Biol. Sci. 2024; 20(7): 2698-2726. doi:10.7150/ijbs.91832
Abstract Full text PDF